Isaac Repentance - All Cards & Runes Tier List Community Rankings
The Isaac Repentance - All Cards & Runes Tier List below is created by community voting and is the cumulative average rankings from 11 submitted tier lists. The best Isaac Repentance - All Cards & Runes rankings are on the top of the list and the worst rankings are on the bottom.
In order for your ranking to be included, you need to be logged in and publish the list to the site (not simply downloading the tier list image).
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Best Isaac Repentance - All Cards & Runes Ranking last updated: 01/22/2026
Isaac Repentance - All Cards & Runes Tier Lists
